De Dan Mirahorian: Les Huit Méridiens Extraordinaires

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    Hynčík L. On the other hand, the development of a particular human body model for all of us is not possible.

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    That is why scaling and morphing algorithms has started to be developed. The current work describes the development of a tool for scaling of the human models. The idea is to have one or couple of standard model s as a base and to create other models based on these basic models.

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    One has to choose adequate anthropometrical and biomechanical parameters that describe given group of humans to be scaled and morphed among. Nevertheless, the cell-intrinsic mechanism of this clock is present in most cells of the body. We have shown previously that for individuals of extreme chronotype "larks" and "owls", clock properties measured in human fibroblasts correlated with extreme diurnal behavior.

    Human physiological period length was estimated via the secretion pattern of the hormone melatonin in two different groups of sighted subjects and one group of totally blind subjects, each using different methods.

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    Fibroblast period length was measured via cyclical expression of a lentivirally delivered circadian reporter. Within each group, a positive linear correlation was observed between circadian period length in physiology and in fibroblast gene expression.

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    Interestingly, although blind individuals showed on average the same fibroblast clock properties as sighted ones, their physiological periods were significantly longer. Based upon differences among sighted and blind subjects, we also speculate that period can be modified by prolonged unusual conditions such as the total light deprivation of blindness.

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